 Tyrosinase is a widely distributed enzyme that plays an important role in melanogenesis and enzymatic browning, making its inhibitors attractive as depigmentation agents in cosmetics and medicinal industries, as well as anti-browning compounds in food and agriculture. Many natural, semi-synthetic and synthetic inhibitors have been developed through various screening methods, with this review focusing on those discovered and biochemically characterized in the last for decades. This article was authored by Salmanez Al-Ghajri, Asiya Barami, Mamed Tariq Hassan Khan and others.