 This study proposed a novel method for creating a hybrid tracheal graft that can be implanted into the body without requiring a second surgery. The hybrid graft consists of a decelularized trachea scaffold coated with polycaper lactone and seated with endothelial progenitor cells, EPCs. The EPCs are then used to form a microvascular network within the graft, allowing it to rapidly vascularize and support cell growth. This method allows for the creation of a fully functional and perfusable vascular network within the graft, which is essential for its long-term survival and functionality.