 This study investigated the effects of caesidium aromaticum, clove, on polycystic ovary syndrome, PCOs, in rats. The results showed that PCOs rats had increased levels of oxidative stress, apoptosis, and autophagy compared to healthy controls. Additionally, the rats exhibited decreased levels of insulin and testosterone, as well as elevated levels of aromatase. Treating the PCOs rats with low doses of clove reduced oxidative stress, apoptosis, and autophagy, while also increasing insulin and testosterone levels. Furthermore, the rats' testosterone levels were lower than those seen in the control group, suggesting that clove may have a direct effect on testosterone production. Overall, these results suggest that caesidium aromaticum, clove, can reduce oxidative stress, apoptosis, and autophagy in PCOs rats, which may lead to improvements in insulin and testosterone levels. This article was authored by Mali Sultani, Mariam Magimian, Seid Hossein Abtahi Avari, and others.