 This study investigated the metastatic patterns and prognostic factors of neuroblastoma, NB, in children. It found that the majority of patients with NB had distant metastases, with the bones and livers being the most common single metastatic sites. Patients with NB who are age less than one year, male, have an adrenal primary site, unilateral tumour, a tumour size greater than 10 cm, neuroblastoma not otherwise specified, NB NOS, second malignant neoplasm, or who chose radiotherapy and chemotherapy were more likely to develop distant metastases. Furthermore, metastatic NB has unique clinical pathologic features, with the bones and livers being the most common single metastatic sites. This suggests that more aggressive treatment should be recommended for high-risk children with NB displaying distant metastases. This article was authored by Shan Liu, Wei Min Yin, Yao Bin Lin, and others.