 The Senate and House of Representatives have identified rising rates of chronic conditions as a major public health concern. These conditions are defined differently than they were in 2010, but there is still a lack of understanding about how these conditions affect women differently than men. To better understand this issue, a clinical framework was developed to measure the NIH's investment in research related to chronic conditions in women. This framework showed that the knee has not been sufficiently focused on the needs of women with chronic conditions. To address this gap, the knee should expand its research focus to include more women-centered studies, create clinical trials networks with broader eligibility criteria, and use data science to better understand the effects of multiple morbidities on women's health. This article was authored by Sarah M. Temkin, Elizabeth Barr, Holly Moore, and others.