 Polyphenol from plants such as fruits and vegetables are phytochemicals with physiological and pharmacological activity as potential drugs to modulate oxidative stress and inflammation associated with cardiovascular disease, chronic disease, and cancer. Due to the limited water solubility and bioavailability of many natural compounds, their pharmacological applications have been limited. Researchers have made progress in the development of nano and microcarriers that can address these issues and facilitate effective drug delivery. These carriers maximize the fundamental effects in various aspects such as absorption rate, stability, cellular absorption, and bioactivity of polyphenol. As a result, polyphenol-based drugs can be used to inhibit cancer cell proliferation, growth, and angiogenesis. This article was authored by Kang Hee Kim, Miran Ki, Ki Ha Min, and others.