 This two-sample Mendelian randomization, MR, study evaluated the potential bi-directional causal relationships between gut microbiota and periodontitis using summary statistics from genome-wide association studies, GWAS. The results suggest that order entero-bacterials, family-bacteroids S24.7 group, genus lachnospiracea UCG008, genus prevotella7, and orderposter alleles may be associated with a higher risk of periodontitis, while genus ruminiclostridium VI may be linked to a lower risk. The reverse MR analysis also identified for microbiota genera that were genetically predicted to be down-regulated in periodontitis and two that were predicted to be up-regulated. Overall, the study provides fresh insights for the prevention and management of periodontitis. This article was authored by Shijinyi, Bin Liu, Yijing Bai, and others. We are article.tv, links in the description below.