 Lipases are industrially important enzymes that catalyze reactions involving fats and oils. The lid domain of lipases is a mobile region that regulates their activity and substrate specificity. Recently, there has been significant progress in understanding how the lid domain affects lipase activity and stability. Computational models have been developed to explain the relationship between the mobility of the lid domain and its effect on lipase activity and stability. This article was authored by Faiz Iqbal Khan, Faiz Iqbal Khan, Dongming Lan, and others.