 This study aimed to identify subgroups differently affected by the pandemic in terms of psychological status and investigate the role of psychological status and trust in information as possible mediators of the relationship between individual characteristics and vaccine hesitancy, VH. The study found that VH decreased with the increase of psychological impact and past vaccination refusal, age 45-54 years, and lower than average income were indirectly related to higher VH through mistrust in COVID-19 information. However, the psychological impact counteracted the greater VH in females, the negative effect of social media among youngest, less than 35 years, and the negative effect of mistrust in the lower than average income subgroup. The study provides a more comprehensive picture of VH determinants that can be used by public health stakeholders to effectively design and adapt communication campaigns. This article was authored by Eliza Maetti, Chiara Reno, Francesco Sanmarchi, and others. We are article.tv, links in the description below.