 This study explores the use of bifunctional degraders that combine Arilidine indolinones, BDE lipoprotein chaperone ligands, BRD2-3-4, bromodomain containing proteins, and BTK, and BLK kinases to target protein degradation through autophagy. However, the resulting degraders do not induce macroautophagy but instead direct their targets to the ubiquitin proteasome system. The study identifies that Arilidine indolinones covalently bind DCAF11, a substrate receptor in the CUL4AB-RBX1-DDB1-DCAF11 E3 ligase, and defines a drug like DCAF11 ligand class that enables exploration of this E3 ligase in chemical biology and medicinal chemistry programs. The Arilidine indolinone scaffold is found frequently in natural products, raising the question whether other E3 ligand classes can be found among natural products and related compounds.