 Sacomas are characterized by high levels of genomic instability and effective homologous recombination repair, HR. These characteristics lead to a unique transcriptomic profile which can be used to identify patients who may respond to targeted therapies such as poly, ADP, ribose, polymerase, PARP, inhibitors. Additionally, these patients may also be sensitive to DNA damaging agents when combined with inhibitors of DNA repair pathways. This article was authored by Lara Planes-Paz, Alicia Pliego-Mendietta, Catherine Hoggadorn, and others.