 copper is an essential micronutrient that plays a crucial role in various physiological processes in all cell types. However, excessive accumulation of intracellular copper can induce oxidative stress and disrupt cellular function, leading to the development of copper-related diseases such as Wilson's disease, neurodegenerative diseases, and cancer. Recent studies have identified a novel form of cell death called cuproctosis, which is distinct from other known pathways underlying cell death. Cuproctosis occurs when copper binds to lipolylated enzymes in the TCA cycle, leading to protein aggregation, proteotoxic stress, and ultimately cell death. The mechanisms that regulate cuproctosis are not fully understood, but recent studies have shed light on its implications in various disease conditions and its potential therapeutic value. This article was authored by Li Yunchen, Zhu Yunche Minnet, and Fu Diwang. We are article.tv, links in the description below.