 The study aimed to identify subgroups of pediatric practitioners based on their HPV vaccine recommendation patterns using latent class analysis and multinomial logistic regression, revealing three distinct profiles, engages, protocol followers, and ambivalent HPV vaccine recommenders. Practicing in a suburban setting was associated with being an ambivalent recommender. The findings highlight the importance of continued efforts to promote evidence-based approaches to HPV vaccine recommendation among practitioners, particularly among the ambivalent group. This article was authored by Suelyn Hopfer, Margaret E. Wright, Harry Pelman, and others.