 The study presented here has provided new insights into the interactions between the plasmodium vivax duffabinding protein, PVDBP, and the Duffy antigen receptor for malaria at DARC receptor. It was found that a sulfated tyrosine residue on DARC interacted with a charged pocket on PVDBPRII, providing a better understanding of how the two proteins interact. Additionally, the study identified the epitope for vaccine-elicited growth inhibiting antibody DB1, which could be used as a basis for developing vaccines and therapeutics against malaria. This article was authored by Riem Morskowitz, Tosa Paul Foulturi, Sofia M. Donvito, and others.