 The receptor for advanced glycation end-products, RAGE, is a transmembrane receptor of the immuno-globulin superfamily. Interaction with RAGE ligands induces a series of signaling cascades and induces NFB activation, as well as downstream effects involving expression of cytokines, chemikines, and adhesion molecules. The functional importance of RAGE in the pathogenesis of a wide range of inflammation-associated conditions remains to be fully realized. The current study provides a comprehensive understanding of the mechanism through which RAGE signaling contributes to the pathogenesis of the aforementioned inflammation-associated conditions. This article was authored by Yor-Kwang-Chua, Rusleysa basa, Honeytalib, and others.