 Eight parental genotypes and their 16F1 crosses were evaluated under normal and salt stress to analyze cotton response to salinity, revealing that SCA estimates were higher than GCA, indicating non-additive gene action. Karkashan, MS-71, and CRS-2007 were found good general combiners, while FH-114 times FH-312 was the best specific combiner. FH-114 times Karkashan and FH-114 times FH-312 demonstrated significant heterosis for most traits under normal and salt stress conditions, and salt tolerance ability is controlled by a few dominant genes in the identified genotypes. This article was authored by Mohammed Mubashat Safar, Abdul Wazakh, Mohammed Away Farouk, and others.