 This study compiles a list of 1261 proteins believed to be differentially expressed in human cancer, which could serve as potential plasma biomarkers for early cancer detection and monitoring with sensitive specific assays. The candidates include proteins involved in various biological processes such as oncogenesis, angiogenesis, development, differentiation, proliferation, apoptosis, hematopoiesis, immune and hormonal responses, cell signaling, nucleotide function, hydrolysis, cellular homing, cell cycle and structure, the acute phase response, and hormonal control. While many have been detected in tissue or nuclear components, it is hypothesized that most should be present in plasma at some level. Out of the 1261 candidates, only nine have been approved as tumor-associated antigens by the FDA. The study proposes that systematic collection and large-scale validation of candidate biomarkers would fill the gap between basic research and clinical use of advanced diagnostics. This article was authored by Malupolansky and N. Lee Anderson. We are article.tv, links in the description below.