 This paper proposes a new classification system for non-insulin glucose lowering drugs. The authors divide these drugs into four categories, insulin secretagogues, insulin sensitizers, calorie restriction memetics, and calorie restrictors. These categories are based on their mechanism of action and potential therapeutic benefits. The proposed classification system can serve as a guide for both students and practitioners, providing a clear understanding of the different types of drugs available for treating diabetes. This article was authored by Sanjay Kaurra, Sauravarora, and Nitin Kapoor.