 Pseudomonas originosa is a bacteria that can cause serious infections in humans. It has developed multiple mechanisms for resisting antibiotics, such as multidrug efflux pumps. These pumps are also responsible for the regulation of quorum sensing, which controls the production of virulent factors like piosynin and LASB. Additionally, these pumps are involved in the metabolic processes of the bacteria, such as the production of phenylethylamine. This metabolite has been shown to reduce the expression of genes related to quorum sensing and virulence, thus reducing the bacteria's ability to cause disease. This article was authored by Ada Munoz-Cazala, Jose L. Martinez and Pablo Laborda.