 Welcome to our pre-filled Zurich Seminar part number four. My name is Klaus Ulhe and I am a senior product manager at Synthekon Technology in Kreisheim, Germany. Today, we want to talk about a very important step, the top opening. The tyvek lid and liner have to be removed in the sterile area. I'm very happy to have a guest today, JP from DuPont. He will give us some insights about the functionality of the tyvek lid and the liner. JP. Hello, my name is Juhabe Kapoor and I'm a technical marketing specialist for Tyvek Healthcare Packaging at DuPont. Thank you, Klaus, for inviting me. Yeah, thank you, JP, for joining me. And what we see here is our top opening machine. As you see, the back is removed now and we have the top there still closed with the tyvek. And then it's going to the top opening itself. So we have two stations mainly. It's the preheating and the opening station with our pharma handling unit. It's a Synthekon pharma robot. So we are preheating the rim for facilitating the opening process and we cut a corner for better gripping. We call it the coffee cream concept. And now JP will give you some more insights about the functionality of the lid and the liner. JP. The top that we see here is heat sealed with a lid made of Tyvek 73B. And the lid together with the top forms a sterile barrier system that maintains the reality inside the container and, of course, within the preferable syringes. And this heating station that you see here is almost like a reverse process to heat sealing the lid on the top in the first place. And it's really a good practice. The lid is usually coated with adhesive for improved clean peel performance. Most of the coatings used for this kind of application can be simply described as being hot melt or water-based coatings. And the coatings are usually applied all over the inner surface of the seal. Sometimes it could be that the sewn coated technology are used to only apply the coatings on the sealing areas. Anyway, remembering that we are within the probably create a clean room environment with strict requirements on contamination control, contaminating particles, the opening of the top is a critical process step here. Yeah, and JP, what about the inlay? What is the functionality of that inlay? Exactly. So when the seal is removed, you will see an inlay or an insert, and that's also made of Tyvek 1073B. And it is to protect for any particles from falling into the syringes when the lid is actually being removed. Even if the leading material itself is not really producing contaminating particles, the coatings applied to the inner surface of the lid are a source of particles for which the inlay is protecting the prefillable syringes. So inlay is essentially a effective way to minimize the contamination risk before the prefilled syringes are exposed and transferred to the filling line. Okay, thank you very much JP, and thank you to the audience for listening. Please give us your feedback. Did you find that video useful? What topics do you want to see in the future? So thanks again to JP, and thanks for listening, and see you again on this channel. Thank you.