 Extensive efforts have now characterized the somatic molecular alterations in human breast cancer, cancer genome atlas network, Stevens et al, and have led to a redefinition of the disease as a constellation of 10 distinct driver-based subtypes, in-clust subtypes, Curtis et al. The pursuit of druggable targets for each of these subtypes is now pressing. This is elegantly illustrated by the work of Lou et al. This article was authored by Heggy G. Russens and Carlos Galdas.