 The Cure America's Guatemala Maternal and Child Health Project, 2011 to 2015, included implementation research designed to assess the effectiveness of an approach called CBIO+, composed of, 1, the census-based, impact-oriented, CBIO approach, 2, the care group approach, and, 3, the community birthing center approach. This is the second paper in a supplement of 10 articles describing the implementation research and its findings. This article was authored by Henry B. Perry, Mario Valdez, Stanley Blanco, and others.