 With the increasing obtainability of multi-OMICS data comes the need for easy-to-use data analysis tools. Here, the authors introduce Metascape, a biologist-oriented portal that provides a gene list annotation, enrichment, an interactome resource, and enables integrated analysis of multi-OMICS datasets. This article was authored by Yin-Yao Zhu, Bin Zhu, La's Parsh, and others.