 The human coronavirus NL63, H-CoV-NL63, is a virus that can cause both mild and severe respiratory illnesses. Recently, it was found to share similarities with the SARS-CoV-1 and SARS-CoV-2 viruses, including the ability to bind to the same receptor. To better understand how this virus interacts with its host cells, researchers have used Creo-electron microscopy to study the structure of the virus's spike protein. They found that the virus's spike protein has a unique structure compared to the SARS-CoV-2 virus, suggesting that the virus may require different receptors to infect cells. This new knowledge could be used to develop treatments for H-CoV-NL63 infections. This article was offered by Kaming Jong, Shan Shan Li, Grigor Pinterli, and others.