 The evolving mutants of SARS-CoV-2 have made the COVID-19 pandemic sustained for over three years. In 2022, BA.4 and BA.5 were the Omicron variants dominating the spread globally. Although COVID-19 was no longer a public health emergency of international concern, PHIC, as announced by WHO, the SARS-CoV-2 variants remain a challenge to global health care under the circumstances of withdrawal and loosening of personal protective behavior in the post-quarantine era. This study aims to acknowledge the clinical characteristics caused by Omicron BA.4-BA.5 in COVID-19 naive people and analyze possible factors affecting disease severities. In this retrospective study, we report and analyze the clinical features of 1820 COVID-19 patients infected with the BA.4-BA.5 Omicron variants of SARS-CoV-2 during a local outbreak that occurred in Macau SAR, China, from June to July 2022. A total of 83.5 percent. This article was offered by Ho Han Chong, Fang Aishio, Chi Chung Chan, and others. We are article.tv, links in the description below.