 An upconversion nanoparticle, UCNP, based antigen-capturing nanoplatform combines phototherapy and immunotherapy to treat metastatic cancers with the ability to selectively destroy primary tumors and inhibit untreated distant tumors. The synergized photothermal, photodynamic, and immunological effects using light-activated UCNP slash ICG slash RBML induces a tumor-specific immune response with about 84 percent of treated mice achieving long-term survival and 34 percent developing tumor-specific immunity. This article was authored by Meng Wang, Jun Song, Fief and Zhou, and others.