 Dear students, in this topic we shall discuss the blood supply to the nephron. The kidneys are very small organs which have only 1% weight as compared to the total body weight. However, they receive remarkably large blood flow that is about 20-25% of total cardiac output. Due to this high blood flow, kidneys can filter the total blood volume equivalent every 4-5 minutes. Dear students, now we shall discuss the blood supply to the nephron. First we shall discuss the efferent pathway. The renal artery which supplies blood to the kidney gives off branches called the interlobular arteries which project into the cortex. These interlobular arteries subdivide further to form a series of short efferent arterioles. These efferent arterioles supply blood to the renal carpacel of each nephron. In the nephron, they divide further to form a network of glomerular capillaries. Now we shall discuss the efferent pathway of nephron's blood supply. The glomerular capillaries recombine to form an efferent arteriole, not vein. The afferent and efferent arteriole are different so that in the efferent arteriole, there is less flow rate as compared to the efferent arteriole. So glomerular capillaries have higher pressure because of low resistance input pathway and high resistance output pathway of efferent arteriole. The efferent arteriole after leaving the renal carpacel divides profusely and forms another plexus of capillaries which is called peritubular capillaries. This is how the efferent arteriole was formed from glomerular capillaries and then a network of capillaries is formed which is called peritubular capillaries. These peritubular capillaries surround proximal and distal convoluted tubules and loop of henle. The peritubular capillaries which surround the loop of henle are termed as vesarecta. The vesarecta start in the cortex, then enter medulla along the descending loop of henle and re-enter the cortex with ascending loop of henle. Now, these peritubular capillaries, they recombine and drain into an interlobular vein. Interlobular veins from different nephrons drain into a renal vein that leaves the kidney.