 The review summarizes the main characteristics of polyhydroxyalkanotes, PHAs, production methods, including the use of cupriavidus necator as the most studied microorganism, the highest productivity achieved with azohydromonaslata, the fed batch cultivation system being the most commonly used at industrial levels and the potential benefits of using continuous systems. Additionally, the review highlights the technical limitations associated with PHA production, such as substrate selection, polymer type, and metabolic characteristics. This article was authored by Wilman Alcarez-Sapata and Ruben Jaramillo-Sanchez.