 The Global ayahuasca survey found that 69.9% of respondents experienced some form of physical adverse effect after consuming ayahuasca, while 55.9% reported experiencing some form of mental health effect. The survey also revealed that older age, physical health conditions, and previous substance use disorder diagnoses were all correlated with increased likelihood of experiencing both physical and mental health effects. Additionally, those who consumed ayahuasca in a non-supervised setting had a greater chance of experiencing physical adverse effects, while those who attended ceremonies in a religious setting had a lower chance of experiencing mental health effects. This article was authored by Jose Carlos Busso, Oscar-Andean, Jerome J. Saris, and others.