 Kispeptin is a neuropeptide that regulates the production of gonadotropin-releasing hormone, GNRH. It was first discovered in 2003 and its role in the regulation of GNRH secretion was confirmed soon after. Since then, researchers have uncovered more about how Kispeptin works, finding that it interacts with the GPR-54 receptor on cells in the hypothalamus, pituitary, and gonads. This interaction is further modulated by endocannabinoids, gabaragic neurons, and other chemical agents. Additionally, researchers have identified a group of neurons called KND in the anterior rostral cerebellar nucleus, ARC, that influence the release of Kispeptin. These findings suggest that Kispeptin may be used as a diagnostic marker for various conditions such as precocious puberty, puberty conformation, hypogonadism, infertility, and polycystic ovary syndrome. This article was authored by Sikander Hayat Khan and Nair Chaudhry. We are article.tv, links in the description below.