 In summary, this study found that Babesiosis is still a rare zoonotic disease in Spain, with an increasing incidence rate over time. Most cases occur in middle-aged men from urban areas during the summer and fall seasons. The Castilla-Monsha and extra-Madura regions had the highest number of cases. Clinicians should have a low clinical suspicion given the low rate of primary diagnoses and high number of readmissions. Mortality was 6.9%, with two deaths being due to secondary diagnoses of the disease. This article was authored by Hugo Almeida, Amparo Lopez-Burnas, Beatriz Rodríguez Alonso, and others.