 Trichosporin species endocarditis is a rare but serious condition that can affect patients who have undergone heart surgery. It is characterized by massive valvular vegetation formation, severe embolic complications, and poor outcomes. There is currently no consensus on treatment, but amphotericin B and azoles are typically used. Prompt surgical intervention is also important for survival. This article was authored by Alice Newell, Francesco Rossini, Alessio Solima, and others.