 This research paper examines the role of the myofibroblast specific transcription factor MRTFA in renal fibrosis. The authors found that MRTFA interacts with TEA domain transcription factor 1, TEAD1, to regulate the expression of ZeB1, which then contributes to fibroblast myofibroblast transition, FMIT. Knockdown of ZeB1 or IRF9 reversed the effects of MRTFA depletion, suggesting that these two genes are key components of the MRTFA ZeB1 Iof9 axis. Furthermore, screening for small molecules that target this axis could lead to potential therapeutics for renal fibrosis. This article was authored by Chen Wenjiao, Ting Huixiao, Yu Wenxiu, and others.