 The marigold flower, collingially aficinalis floss, is a widely used plant raw material in traditional phyto-medicine due to its rich chemical composition, which includes flavonates and terpenates such as oleanolic acid derivatives. Its biological activity profiles, including anti-inflammatory, antimicrobial, immunostimulatory, and antioxidant properties, make it useful in treating dermatological diseases. Recent studies have shown that C. aficinalis also is cardioprotective, hepatoregenerative, pancreas regenerating, neuroprotective, and even anti-cancer activities, and is used in cosmetology and the food industry. This article was authored by Agnieszka-Sopa, Marta-Climax-Ksekidowicz, Carolina Jaffronik, and others.