 Abstract migraine is a severe neurovascular disorder characterized by recurrent headaches accompanied by symptoms such as nausea, vomiting, and sensitivity to light and sound. It is believed that migraines are caused by a combination of genetic factors, environmental triggers, and hormonal fluctuations. Prolactin and oxytocin are two hormones that have been implicated in the pathogenesis of migraine. Prolactin is thought to increase the excitatory activity of neurons in the trigeminal brainstem pathway, while oxytocin is thought to reduce this activity. The targeted treatments for migraine based on manipulation of these hormones could provide relief from the debilitating symptoms of migraine. This article was authored by Anna K. Shichik, Samayulitas, Tulinaktak, and others.