 Six-month-old male mice were divided into three groups, n equals 8, to study the effect of enriched environment on cognitive function and pathological changes in Alzheimer's disease mice. The results showed that the enriched environment improved the behaviors of AD mice, reduced a deposition in the brain, regulated cytokine levels, but these improvements were short-term. This article was authored by Yu Wei Zhong, Ji Yi Wang, Lin Wang, and others.