 This paper reviews the literature on Stevens-Johnson syndrome, SJS, and toxic epidermal necrolisis 10, 2 rare but serious skin conditions caused by an acute exposure to ultraviolet radiation, UVR. It summarizes the common features of these cases, including the delayed onset of symptoms after UVR exposure, the presence of a non-linear distribution of target-like lesions, and the absence of a flu-like prodrome. Additionally, it discusses the potential pathogenesis, differential diagnoses, and proposed diagnostic criteria. This paper provides valuable insight into the potential link between UVR exposure and SJS-10, which could lead to improved preventative measures and better treatment options. This article was authored by Blake Geoffrey McKinley, Mitchell Edger Allen, and Nicole Michels.