 This study used gene expression data from synovial tissue and macrophages to identify common differentially expressed genes, DEGs in rheumatoid arthritis, R.A. reconstruct protein-protein interaction, PPI, networks, and determine key biomolecules involved in R.A. pathogenesis. The results identify hub proteins such as STAT1, I.C.2, and KYNU, receptors like PPD, transcription factors including NR4A1, MEOX2, and IRF1, and key myrnus such as MIR-299, MIR-8078, MIR-3659, and MIR-6882. The study suggests that these biomolecules may be drug targets or used for diagnostic strategies in R.A., but further experimental validation is needed. This article was authored by Bitul Khamipay and Esra government.