 Collagen-based biomaterials are widely used in tissue engineering due to their biodegradability, biocompatibility, availability, and versatility, but sterilization remains challenging as it alters its structure. This review provides a comprehensive overview of collagen-based biomaterial applications in tissue engineering for regenerative medicine use. This article was authored by Francois Berthaud, Robert Govan, and René Perrento-Barrell.