 So, again, thank you to the Brain Foundation and the donors and organisers and the scientific committee for awarding us this grant. And Yana is particularly devastated to not be able to come today, but she's delighted to have delivered her son on Thursday, so it was a bit tight timing. So just a bit in the background of the team. So Yana is a neuroscientist who works in studying the development of the brain and focuses on traumatic brain injury. Mark Rutenberg studies, is a neuroscientist who studies spinal cord injury. I'm actually, I did a PhD in neuroscience quite a while ago, but for the last 20 years have been working in immunology. And over in the last two years or so we've formed a team where we've been focusing on trying to understand the impact of the immune system following injury in both in traumatic brain injury and spinal cord injury. And so we've been interested in understanding the cells that infiltrate the brain, the immunological pathways that are activated, and the mechanisms that drive cell death and pathological differentiation and injury, perpetuation of injury in the brain. One of the pathways that we found to be activated early after traumatic brain injury is the Rho Kines pathway and particularly ROT2. And that's the basis of the grant, the study that this grant will be funding. So ROT2 in multiple disease, inflammatory disease settings has been shown to drive pathological differentiation of immune cells as well as tissue resident cells. And it's been shown by blocking this pathway early on, you can attenuate inflammation and limit disease. And because of these studies, there's been a number of clinical trials using a small molecule inhibitor of ROT2, and it's been shown to be efficacious in limiting inflammation in diseases such as psoriasis, pulmonary fibrosis, and chronic graft-phrosis host disease. So having seen that ROT2 is elevated immediately after traumatic brain injury, we're interested in understanding whether this pathway is driving pathology and whether blocking this pathway will allow a means to improve outcomes of traumatic brain injury. So thank you.