 In this systematic review, it was found that the use of integrase inhibitor-based antiretroviral therapy was associated with a small increase in weight and small decreases in lipid serum levels compared to protease inhibitor or NNRTI-based therapy in HIV patients. However, there was a high risk of bias in two RCTs and some concerns about bias in two RCTs. Therefore, further research is needed to confirm these findings. This article was authored by German Valenzuela Rodriguez, Carlos Diaz-Eracutipa, Janie Collins, and others.