 The study found that even though two transcription factors Cephas and C.jun are co-ordinately expressed at the population level, their expression is noisy and uncorrelated with each other in individual cells. Despite this, the induction of downstream genes by these heterodimers is insensitive to the number of heterodimers in individual cells, due to sequestration of promoters within compact chromatin. This suggests that barriers to noise propagation and amplification are commonplace in higher eukaryotes. This article was authored by Kirti Shah and Sanjay Tiyagi.