 Good morning to one and all, with today's session we are going to learn about organic reactions and synthesis of drug molecules. Learning outcome, at the end of this session students will be able to explain the synthesis of drugs and uses of drugs. Content, we are going to learn about synthesis of the drugs like paracetamol, aspirin, ibuprofen and uses of the same drugs that is paracetamol, aspirin and ibuprofen. Synthesis of paracetamol, it is synthesized by reacting four amino phenol with acetic anhydride. A reaction mixture is kept for reflux for 15 minutes with continuous stirring. An amide bond is formed between the two molecules and acetic acid is obtained as a by-product. When the reaction is complete the paracetamol is then isolated by filtration and purified by recrystallization in hot water. This is the reaction to explain the formation or synthesis of the paracetamol. This is for amino phenol when reacts with or when reflects with acetic anhydride. This gives us paracetamol molecule but along with this acetic acid molecule is also formed. This can be explained with graphical presentation. This is for amino phenol molecule when it is refluxed with acetic anhydride this gives us paracetamol and this is acetic acid molecule uses of paracetamol. It is commonly used as a drug as an analgesic, anti-inflammatory, anti-pirated. Analgesics means pain relieving drugs, anti-inflammatory means swelling are reduced and anti-piratic means temperature is reduced. It is used to treat colds and fever, headache, muscular pains, arthritis, back bone pain, tooth aches etc. but the overdose of a paracetamol causes damage to the liver. We can learn more precisely. Well this video gives us and precise information regarding the use of paracetamol, side effects of the paracetamol etc. The second drug that we are going to learn it is regarding aspirin, synthesis of aspirin. It is synthesized by acetylation of salicylic acid with excess of acetic anhydride. A small amount of strong acid like phosphoric acid is used as a catalyst which speeds up the reaction. The excess of acetic acid is removed by addition of water. The crude aspirin obtained is purified by recrystallization in hot ethyl alcohol. This can be explained once again with this graphical presentation. This is salicylic acid when it is treated with the acetic anhydride. This gives us aspirin but along with this acetic acid is also formed. This is a regular reaction to explain this formation of aspirin molecule uses of aspirin. Aspirin is one of the commonly used drug as analgesic, antipyretic, anti-inflammatory and anti-reumatic. Thus it is used in headache, cold, tissue swelling, arthritis etc. So at this moment pause the video and answer the question. The question is aspirin is synthesized from A salicylic acid and acetic anhydride, B oxalic acid and acetic anhydride, C nitric acid and acetic anhydride and D sulfuric acid and acetic anhydride. Well the answer that is aspirin is synthesized from A salicylic acid and acetic anhydride. Third synthesis that is synthesis of ibuprofen. Ibuprofen can be prepared by green synthesis with following three steps. Step one, acetylation of isobutyl benzene using acetic acid in presence of hydrogen fluoride as a catalyst. Step two, hydrogenation of acetyl product using runny nickel catalyst to convert a carbonyl group to hydroxyl group and step three, it is oxidation using carbon monoxide and palladium catalyst to get ibuprofen. This is the reaction to explain this. This is isobutyl benzene when it is treated with acetic anhydride in presence of HF it gives as product which on hydrogenation with runny nickel and on further we can say the formed product is further oxidized by using carbon monoxide and palladium this gives as ibuprofen. This is graphical presentation for this synthesis of ibuprofen and the ultimate product is formed after this oxidation that is ibuprofen. We can go for this video tube of YouTube video for this uses of ibuprofen. When the intravenous administration is politically justified not possible other routes of administration mode of administration of the world like ibuprofen administered with meals or milk especially if you notice digestive discomfort via intravenous injection administer as an intravenous infusion over 30 minutes. Cautions and warnings of failure of ibuprofen moderate hepatic, lower initial dose, moderate renal insufficiency, reduced initial dose, elderly, children with severe dehydration, background, ulcerative colitis, or prone hypertension or heart failure, bronchial plasma, allergic reactions, hematopoietic disorders, lupus erythematosasorum, mixed connective tissue, side effects of ibuprofen can be aphtic ulcer, perforation and gastrointestinal bleeding, nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melina, hematomasis, ulcerative stomatitis, exacerbation of ulcerative colitis, and of prone fatigue or drowsiness, headache, dizziness, vertigo, skin rash. Well the uses of ibuprofen, ibuprofen is used primarily to treat fever, mild to moderate pain including pain after surgery, painful menstruation, osteoarthritis, dental pain, headaches, pain from kidney stone, etcetera. So, for this I have used a reference book that is a comprehensive industrial chemistry by Dr. P. J. More and also the YouTube links, these are YouTube links for the videos that I have added to this particular session. Thank you.