 This study assessed the prevalence of comorbidities, severity and mortality with regard to geographic region, age, gender and smoking status in patients with COVID-19. The results showed that the prevalence of hypertension, obesity, diabetes, asthma, hospitalization, intensive care admissions and mortality were significantly higher in European countries compared to other regions. Additionally, the prevalence of hypertension and asthma was higher in older adults, while the prevalence of diabetes was higher in men. Furthermore, the prevalence of hospitalization and mortality was higher in observational studies compared to case control studies. This article was authored by Santana Chentsula, Kota Vidyasagar, Salman Patan and others.