 The biomechanical response of cortical and trabecular bone tissues is important for understanding how dental implants function. When there is a mismatch between the implant and the surrounding bone, the interaction between them must be interpreted in the context of the biomechanical response of the bone tissue. This includes the loading induced by the implant, as well as the changes in the bone over time during the healing phase. Clinicians should also consider the bone's response to the implant frame configuration, the surgery performed, and the changing conditions at the bone implant interface. By integrating these factors into their assessment, clinicians can better understand the biomechanics of the implant and its potential success or failure. This article was authored by Chiara Julia Fontanella, and Manuele Luigi-Carniel, Andrea Parpella, and others.