 This paper introduces a prototype for clinical research documentation using the structured information model HL7 CDA and clinical terminology, SNOME CT. The proposed solution was integrated with the current electronic health record system, EHRS, and in to implement interoperability and structure information and to create a collaborative platform between clinical and research teams. The framework also aims to overcome the limitations imposed by classical documentation strategies in real-time healthcare encounters that may require fast access to complex information. The solution was developed in the Pediatric Hospital, HP, of the University Hospital Center of Quimbra, CHUC, and national reference for neurodevelopmental disorders, particularly for Autism Spectrum Disorder, ASD, which is very demanding in terms of longitudinal and cross-sectional data throughput. The platform uses a three-layer approach to reduce components dependencies and facilitate maintenance, scalability, and security. The system was validated in a real-life context of the neurodevelopmental and autism unit, UNDA, in the HP and assessed based on the functionalities model of EHRS, EHRS FM, regarding their successful implementation. This article was authored by Bruno Diarito, Andre Santos, Susanna Muga, and others. We are article.tv, links in the description below.