 Abstract, this study investigates the role of extracellular regulated protein kinases, ERK, signaling an allograft rejection. Lycorine, an ERK specific inhibitor, was used to treat mice undergoing cardiac allotransplantation. The results showed that Lycorine treatment significantly prolonged allograft survival, suggesting that ERK signaling plays a key role in allograft rejection. Further investigation revealed that Lycorine treated T cells were less responsive to stimulation, leading to metabolic reprogramming and mitochondrial dysfunction. Transcriptomic analysis of these cells revealed an enrichment of genes associated with immune response, the mitogen-activated protein kinase cascade, and metabolism. These findings suggest that ERK signaling plays a critical role in T cell activation and allograft rejection, and provide new insights into the development of immunosuppressive agents. This article was authored by Xiaoxing Tan, Chongxing Qi, Xiang Li Zhao, and others. We are article.tv, links in the description below.