 Epithelial mesenchymal transition, EMT, is a complex molecular program that regulates changes in cell morphology and function during embryogenesis, tissue development, and tumor progression. Cells undergoing EMT expand out of and degrade the surrounding microenvironment to migrate from the primary site. The mesenchymal phenotype observed in fibroblasts is specifically important based on the expression of smooth muscle actin, alpha-SMA, fibroblast growth factor, FGF, fibroblast specific protein 1, FSP1, and collagen to enhance EMT. Tumor epithelial fibroblast interactions that regulate tumor progression have been identified during prostate cancer, and these events influence therapy response and patient outcome. This review addresses how canonical EMT signals originating from prostate cancer fibroblasts contribute to tumor metastasis and recurrence after therapy. This article was authored by Bethany N. Smith and Neil A. Baumick. We are article.tv, links in the description below.