 The article discusses a systematic review of treatment options and outcomes for patients with dissecting cellulitis who have failed standard therapies, including intralesional or topical steroids or antibiotics. Isotrotinoin was the most commonly reported treatment but had limited response, while biologics and laser therapy demonstrated a better chance of remission. X-ray epilation and surgical excision showed the best remission rates, but can be complicated by serious morbidity. The article proposes a regimen for the treatment of refractory cases of dissecting cellulitis and suggests that more robust studies, including randomized controlled trials, are needed to identify preferred treatment options.