 Dear students, in this topic, we shall discuss the control mechanisms of intestinal and pancreatic secretions. Epithelium of mammalian small intestine secretes intestinal juice. This intestinal juice is actually a mixture of two fluid secretions, which are released from the Bruner's glands and crypts of Libar cohen. The Bruner's glands are present in the first part of duodenum between the pyloric sphincter and pancreatic duct. They secrete a viscous enzyme-free alkyline mucoid fluid. This secretion of the Bruner's glands is present at that time or at that place when the pyloric sphincter enters in the duodenum and is not present in the pyloric sphincter and the pyloric sphincter. This secretion is present before the pyloric sphincter and this is an alkyline secretion. Therefore, it enables the duodenum to withstand the acidic chimes coming from the stomach. This action is very necessary because the acidic chimes can damage this portion of the duodenum because there is no secretion of pancreatic juice or pyloric sphincter here. That is why the secretion of the Bruner's glands is a protective function and a neutralizing function which initially neutralizes the acidic chimes. The crypts of Libar cohen are also called mucosal glands. They are dispersed throughout the intestinal folds. They produce a thinner enzyme-rich alkyline fluid. This fluid mixes with the duodenal secretions. The secretions in the duodenum are mixed with the Bruner's glands. Dear students, now we shall discuss the control of these intestinal secretions. Several hormones regulate the secretion of intestinal juices. For example, secretion, hormone, gastric inhibitory peptide hormone and gastrine hormone. Secretion of the secretion of intestinal juices is also under neutral control. Neural control is because the vagus nerve innervates the small intestine and when it stimulates, it increases the secretion of intestinal juices. Distention of the intestinal wall also elicits a local secretary reflex which is caused by the presence of food. Dear students, now we shall discuss the secretions of pancreas. Pancreatic juice enters the duodenum through pancreatic duct. It is an alkyline fluid which is also rich in bicarbonate ions and digestive enzymes. Various digestive enzymes present in pancreatic juice are alpha amylase, trypsine, chymotrypsine, elastases, carboxypeptideases, aminopeptideases, lipases and nucleases. The secretions of pancreatic juice are controlled by a variety of hormones which include peptide hormones, gastrine, polycystokinine, somatostatin and ancafalins. First we shall see the effect of peptide hormones. The peptide hormones sacritin and vasoactive intestinal peptide stimulate the secretion of pancreatic enzymes. The gastrine, when secreted from stomach lining, starts a slow flow of pancreatic juice. When food is in stomach and gastrine hormones are secreted, it affects pancreas and it releases a little bit of it. It is in anticipation of the food coming to duodenum. In this anticipation, pancreatic juice secretion starts. Polycystokinine also affects pancreatic juice secretion. It is an upper intestinal hormone which is secreted in response to fatty acids and amino acids in the spine and elicits secretion of pancreatic enzymes. It also stimulates release of bile from the gallbladder. Dear students, somatostatin has an inhibitory effect on gastric acid and pancreatic secretions. In comparison, N-cafaleins inhibit the secretion of gastric acid but they stimulate pancreatic enzyme secretions.